cross-posted from: https://hackertalks.com/post/7095330

TLDR: Ketone levels above 2mmol/l show significant improvements in patients with Euthymic bipolar disorder.

Of 27 recruited participants, 26 began and 20 completed the ketogenic diet. For participants completing the intervention, mean body weight fell by 4.2 kg (P < 0.001), mean body mass index fell by 1.5 kg/m2 (P < 0.001) and mean systolic blood pressure fell by 7.4 mmHg (P < 0.041). The euthymic participants had average baseline and follow-up assessments consistent with them being in the euthymic range with no statistically significant changes in Affective Lability Scale-18, Beck Depression Inventory and Young Mania Rating Scale. In participants providing reliable daily ecological momentary assessment data (n = 14), there was a positive correlation between daily ketone levels and self-rated mood (r = 0.21, P < 0.001) and energy (r = 0.19 P < 0.001), and an inverse correlation between ketone levels and both impulsivity (r = −0.30, P < 0.001) and anxiety (r = −0.19, P < 0.001). From the MRS measurements, brain glutamate plus glutamine concentration decreased by 11.6% in the anterior cingulate cortex (P = 0.025) and fell by 13.6% in the posterior cingulate cortex (P = <0.001).

These findings suggest that a ketogenic diet may be clinically useful in bipolar disorder, for both mental health and metabolic outcomes. Replication and randomised controlled trials are now warranted.

Full Paper: https://doi.org/10.1192/bjo.2024.841

  • Zerlyna@lemmy.worldMEnglish
    2·
    2 days ago

    Curious, so this is tracked by ketosis values, correct? I’ve been trying to shed some pounds this way, even more reason to keep It up.

    And what exactly is “thought”?

    • jet@hackertalks.comOPEnglish
      1·
      2 days ago

      what exactly is “thought”?

      Everyday participants were asked to rate their speed of thought on a numerical scale

      tracked by ketosis values

      Ketone levels, the study used a ketomojo and participants used a finger prick ketone measurement to log their ketone levels daily.

      shed some pounds this way

      That’s great! I hope it works for you. If you want to talk about it, I’m happy to help. There is a community here for it too [email protected]

  • tetris11@lemmy.ml
    5·
    13 days ago

    Those are some, uh, interesting correlation coefficients, and some, uh, interesting P-values with respect to the relatively low N, for what seems to be a lot of, uh, self-reported metrics relating to feelings.