It’s time to move on from TNG and TOS. We need a new crew on a new Enterprise beginning their voyage 50-100 years after the Dominion War. We need something fresh and most importantly we need hope to return to Star Trek. The vision of a better future is essential to good Trek and it’s mostly been abandoned. Enough with the gritty high drama high action stuff. Trek thrives in philosophical sci-fi and in presenting us with a better version of humanity.
Maybe in the wake of their surrender and Odo rejoining them the Founders step back or even go into isolation entirely. The Dominion collapses and there is widespread fighting in the gamma quadrant as different factions seek to take the Founders place. The new series could primarily be set in that quadrant. Maybe the Federation established a foothold in the gamma quadrant so that they controlled both sides of the wormhole and the Enterprise is there to expand the Federation’s influence. That would give the writers freedom to introduce new antagonists because DS9 did very little actual exploration of the gamma quadrant.
Edit: gamma not delta